Carlo M. Croce, MD

Carlo M. Croce, MD, a renowned cancer geneticist, is the John W. Wolfe Professor of Human Cancer Genetics, Chairman of the Department of Molecular Virology, Immunology and Medical Genetics, Director of the Institute of Genetics, and Director of the Human Cancer Genetics Program at the Ohio State University (OSU) Comprehensive Cancer Center in Columbus, OH. In addition, Dr. Croce is a member of both the Lymphoma Research Foundation's (LRF) Scientific Advisory Board (SAB) and Mantle Cell Lymphoma Consortium (MCLC).

Carlo M. Croce, MD

Dr. Croce received his medical degree, summa cum laude, in 1969 from the School of Medicine, University of Rome in Italy, his native country. "Mapping of the human immunoglobulin loci suggested to me that they could be involved in the chromosome translocations observed in Burkitt lymphoma," said Dr. Croce explaining what originally drew him to the field of lymphoma. "We then showed that in Burkitt lymphoma the human immunoglobulin loci are juxtaposed to the MYC oncogene. Such juxtaposition results in MYC dysregulation leading to lymphoma. Then we exploited other recurrent chromosomal alterations to clone and characterize other genes involved in human lymphoma and leukemias including BCL2." These breakthroughs, in addition to the discovery that alterations in non coding genes cause cancer (microRNAs), are the findings Dr. Croce is most proud of.

He began his widely esteemed medical career as an Associate Scientist and Research Associate at the Wistar Institute of Biology and Anatomy in Philadelphia in 1970. Prior to moving to OSU in 2004, Dr. Croce was an Associate Member (1974-76), Professor (1976-80), and Associate Director and Institute Professor (1980-88) at the Wistar Insitute. He was also Wistar Professor of Genetics (1980-88) and Wistar Professor of Pediatrics (1986-88) at the University of Pennsylvania, a member of the Mammalian Genetics Study Section at the National Institues of Health (1979-83), the Director of the Fels Institute for Cancer Research and Molecular Biology and Professor of Pathology and Medicine at Temple University School of Medicine (1988-91), and Director of the Kimmel Cancer Center (1991-2004). Dr. Croce's "great interest in cancer pathogenesis and the mechanisms involved in cancer causation" keep him engaged in his speciality.

His career has been honored with many awards including The National Institutes of Health Outstanding Investigator Award, the GM Cancer Research Foundation Mott Award, the Gottlieb Award from MD Anderson Cancer Center, and the Henry M. Stratton Medal from the American Society of Hematology (ASH), to name a few. With more than 950 peer-reviewed publications, Dr. Croce's contributions involving genes and genetic mechanisms implicated in the pathogenesis of human cancer are world-renowned.

As a member of LRF's MCLC, Dr. Croce enjoys talking with individuals who are interested in the many aspects of lymphoma research including causes, pathogenesis, diagnostics and treatment. Dr. Croce's current research focuses on the role of non coding RNAs in cancer and he finds the most exciting thing currently going on in lymphoma research to be the development of targeted treatments. Likewise, he recommends newly diagnosed lymphoma patients "be seen by a physician who understands targeted treatment."

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