The LRF Research Program: Overview

The Lymphoma Research Foundation (LRF) supports innovative lymphoma research in keeping with the Foundation's mission, to eradicate this disease.

LRF accomplishes this through a variety of program elements: research grants for young investigators and for senior investigators; spotlights on a variety of disease focus areas; meetings to share new developments and build collaborations and the creation of resources.

Research Grants – LRF supports a spectrum of grant types:

  • Young Investigator Awards are an investment in important work today and in the future. Awarding grants to junior investigators (Fellows and CDAs), when they are likely to be at their most creative so that they can contribute to lymphoma research now, establish themselves professionally, and contribute to the field over a lifetime of work, has been a key part of LRF's mission since 1992.
  • Post-doctoral Fellowships are designed to support research, which may be laboratory or clinic based and relevant to the treatment, diagnosis or prevention of Hodgkin's and/or non-Hodgkin's lymphoma.
  • Clinical Career Development Awards (CDA) fund training of physician investigators who will participate in developing new therapeutics and diagnostic tools for lymphoma.
  • These awards are given to address the full spectrum of all lymphomas and related questions.

To learn more about LRF awards visit the following sections of this website: Types of LRF Grants and Young Investigator Awards

Disease Focus Areas Awards – LRF supports Disease Focus Area (DFAs) awards for several types of lymphoma. These awards go to senior researchers with strong records in the study of lymphoma, the specific disease category and/or in related issues such as genetics, micro-biology or immunology. LRF has given awards supporting research in these forms of lymphoma:

  • Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
  • Diffuse large B-cell lymphoma (DLBCL)
  • Follicular lymphoma (FL)
  • Mantle cell lymphoma (MCL)
  • DFA awards can take several forms. For instance:
    • Senior Investigator Awards – similar to the National Institutes of Health/National Cancer Institute R01 awards are given to established researchers.
    • Correlative Grants – grants to support research projects additional to and associated with existing clinical trials with the aim of enhancing and maximizing the value of the clinical trial's results.
    • Planning Grants – designed to help cross disciplinary or cross institutional teams to plan and write applications to the NIH for a substantial project.
    • Experimental/Developmental Grants – intended to help researchers explore or develop novel basic scientific ideas with a concentration on translational medicine.
    • For more information on LRF Grants go to Grants & Awards and to Disease Focus Areas

Meetings and resources – LRF has produced a variety of meetings designed to share knowledge, foster collaboration and address issues. Here are a few examples:

  • LRF convened the workshop "What Is a Clinically Meaningful Response? — Should Endpoints in CLL Drug Research Be Redefined?" in May 2011 in an effort to examine whether the criteria by which the FDA assesses new therapeutics for CLL should be updated. The U.S. Food and Drug Administration (FDA) was represented at the meeting which was reported on in the Journal of Clinical Oncology, Novel Targeted Agents and the Need to Refine Clinical End Points in Chronic Lymphocytic Leukemia, Bruce Cheson, MD, et al, published on-line July 9, 2012.
  • In October 2011, LRF also produced a special meeting on Follicular Lymphoma Research Directions, which has helped to set the stage for the Foundation's future work on follicular lymphoma and led to the development of more specific Requests for Proposal for all senior researcher awards.
  • The Mantle Cell Lymphoma Annual Workshop, held in early spring, brings together MCL investigators to share their research findings – often pre-publication – thereby speeding advances in the field. There have been workshops annually since 2004 consistently receiving top marks by participants for advancing research.
  • The LRF Mantle Cell Lymphoma Cell Bank was created with the ATCC, the Global Bioresource Center, as an essential reserve for investigators, to provide well characterized cell lines originally created from cancer biopsies.