The Lymphoma Research Foundation (LRF) implements its Research Program around several fundamental concepts: innovative thinking; accelerating results and answering questions; disease focus areas; plus the development of activities and resources that support and advance research results.
- Innovative Thinking:
Young Investigators – Fellowships and Clinical Career Development Awards (CDAs) attract and train promising talent in lymphoma research while accomplishing important research work in the labs of senior mentors and sponsors.
- Accelerating and Answering:
Senior Investigators – Research grants spotlighting LRF's Disease Focus Areas take several forms such as:
- Senior Investigator Awards – similar to the National Institutes of Health/National Cancer Institute R01 awards are given to established researchers. Typical grants are about $150,000-250,000 per year for three years.
- Correlative Grants – grants to support research projects additional to and associated with existing clinical trials with the aim of enhancing and maximizing the value of the clinical trial's results. A typical grant would be $125,000 per year over two years.
- Planning Grants – designed to help cross disciplinary or cross institutional teams to plan and write applications to the NIH for a substantial project. A typical grant would be $25,000 for one year.
- Experimental/Developmental Grants – intended to help researchers explore or develop novel basic scientific ideas with a concentration on translational medicine. A typical grant would be $100,000 per year over two years.
- Disease Focus Areas:
- With the support of generous donors, LRF funds major grants to senior researchers investigating:
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
- Diffuse Large B-Cell Lymphoma (DLBCL)
- Follicular Lymphoma (FL)
- Mantle Cell Lymphoma (MCL)
- Activities and Resources:
- LRF produces scientific meetings where medical researchers can share information and ideas, make connections, and form collaborations. Examples include:
- The Mantle Cell Workshop is an annual program bringing together MCL investigators from around the world to share, learn and network. Presentations are pre-publication which helps to advance the field with ideas and information much more quickly than otherwise. The 2012 MCL Workshop was the ninth such program. The workshop consistently receives high marks from the participants on its ability to advance MCL research.
- Special meetings to answer specific questions or explore issues are also produced as needed. These meetings often help to move the research forward or advance therapy development. For example:
- May 2011 – What is a Clinically Meaningful Response? Should Endpoints in CLL Drug Research Be Redefined? The program explored whether the criteria by which the Food and Drug Administration (FDA) assesses new therapeutics for CLL should be updated. The FDA was represented at the meeting.
- October 2011 – Follicular Lymphoma Research Directions. This special workshop has helped to set the stage for the Foundation's future work on follicular lymphoma identifying key questions requiring attention and support. This in turn led to the development of more specific Requests for Proposal for all senior researcher awards in all LRF funded disease categories.
- LRF has also developed resources such as the Mantle Cell Lymphoma Cell Bank – in partnership with ATCC, the Global Bioresource Center, as an essential reserve for investigators to provide well characterized cell lines, which are used to research the efficacy of experimental drugs.