Understanding basic, translational and clinical research

Basic, translational and clinical research, are the three essential stages necessary to create therapies and cures. Basic research focuses on creating knowledge and understanding of a subject. Translational research aims to take the results of promising findings from basic research to application in a clinical setting. Clinical research is dedicated to testing possible new therapeutics for their efficacy and safety in treating patients. Clinical research has multiple stages, Phases I to IV:

  • Phase I is conducted with a small group of human subjects and is aimed at testing safety.
  • Phase II is carried out with a somewhat larger group and is aimed at testing efficacy and confirming the safety results of Phase I.
  • Phase III are much larger trials carried out at multiple institutions and involve hundreds to thousands of patients. Phase III are the most complex and expensive trials to run.
  • Phase IV is a post-marketing trial designed to further investigate rare or long term use effects, safety with use of other drugs, safety for special groups such as pregnant women, and other such issues which may not have been addressed in the Phase III trial.

Although the LRF Research Program funds grants in all three categories it primarily focuses on basic, translational, and Phase I and II Clinical research.