Follicular Lymphoma: Treatment Options
There are various treatment options for FL based on the severity of associated symptoms and the rate of Abnormal cell growth that cannot be controlled by the body's natural defenses. Cancerous cells can grow and eventually form tumors. growth. If patients show no or very few symptoms, physicians may recommend not to treat the disease right away, an approach referred to as An approach in which no immediate medical, surgical or radiation therapy is given. Patients are followed closely to make sure the cancer does not progress. (“watch and wait”). Studies have shown that patients who are managed with an active surveillance approach have survival outcomes similar to those who are treated early in the course of their disease. With this strategy, patients’ overall health and disease are monitored through regular checkup visits and various evaluations, such as laboratory and imaging tests. Active treatment is started if the patient begins to develop lymphoma-related symptoms or there are signs that the disease is progressing based on testing during follow-up visits.
FL is generally very responsive to radiation and Treatment with drugs to stop the growth of rapidly dividing cancer cells, including lymphoma cells.. Radiation alone can provide a long-lasting The absence of disease. Remission does not necessarily indicate that a person is cured. Patients may have complete or partial remission. in some patients with limited disease. In more advanced stages, physicians may use one or more chemotherapy drugs or the monoclonal a substance made by B-lymphocytes that reacts with antigens on toxins, bacteria and some cancer cells and either kills or marks them for removal. rituximab (Rituxan), alone or in combination with other agents.
Biologic therapies that act specifically against a particular antigen. can act more directly than chemotherapy agents by targeting particular markers found on B-cells and recruiting immune cells to promote An abnormal mass or swelling of tissue, that can occur anywhere in the body. destruction, which can increase response to treatment. Common combination regimens include:
- R-Bendamustine (rituximab and bendamustine)
- R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)
- R-CVP (rituximab, cyclophosphamide, vincristine, and prednisone)
Some monoclonal antibodies can also be used as maintenance therapy for up to two years to prolong remission for patients with no signs of lymphoma. Another treatment sometimes used for FL is A therapy that is prepared by attaching a radioactive isotope to a monoclonal antibody. (RIT) using an agent such as yttrium-90 ibritumomab tiuxetan (Zevalin), which is a radioactive particle connected to an antibody that targets cancer cells.
To learn about treatments under investigation for FL, download the Follicular Lymphoma Fact Sheet.