T-Cell Lymphoma: Relapsed/Refractory
The term “relapsed” refers to disease that reappears or grows again after a period of The absence of disease. Remission does not necessarily indicate that a person is cured. Patients may have complete or partial remission..
The term “A cancer that is resistant to treatment.” is used to describe when the lymphoma does not respond to treatment (meaning that the Abnormal cell growth that cannot be controlled by the body's natural defenses. Cancerous cells can grow and eventually form tumors. cells continue to grow) or when the response to treatment does not last very long.
Patients with relapsed disease are usually treated with Several drugs given together to increase response rate of certain tumors. such as ICE (ifosfamide, carboplatin, and etoposide) if stem cell transplantation is contemplated as the next step in therapy. However, some regimens or transplant might not be suited for everyone because of their high toxicity levels. Less toxic single agent therapies are also available and might induce a long-lasting remission in such patients. These therapies include belinostat (Beleodaq), brentuximab vedotin (Adcetris), pralatrexate (Folotyn), and romidepsin (Istodax). These drugs are approved by the U.S. Food and Drug Administration (FDA) for patients who have relapsed or those who have not responded to their first line of Treatment with drugs to stop the growth of rapidly dividing cancer cells, including lymphoma cells..