Double-Hit Lymphoma

Double-hit lymphoma (DHL) is an aggressiveLymphomas that are fast growing and generally need to be treated immediately. Also called intermediate-grade or high-grade lymphomas. type of B-cell non-Hodgkin lymphoma (NHL) characterized by rearrangements (parts of genesThe basic building blocks of heredity that are present in all cells. Genes are comprised of DNA and other materials. switch places within chromosomes) in two particular genes. One rearrangement involves the MYC gene, and the other involves the BCL2 gene or, less commonly, the BCL6 gene.

With respect to gene mutations, DHL shares many features with two other types of B-cell lymphomas—diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. In fact, about five percent of DLBCLs and about 32 to 78 percent of Burkitt lymphomas have rearrangements of the MYC and BCL2/BCL6 genes and are thus called DHLs. However, research has shown that DHL differs in several important ways from the forms of DLBCL and Burkitt lymphoma that do not have dual gene rearrangements. For this reason, in 2016 the World Health Organization designated DHL as its own category of B-cell NHL.

Molecular tests allow doctors to check for gene rearrangements in chromosomes under a microscope are used to confirm a diagnosis of DHL.

To learn more about double-hit lymphoma, download the Double-Hit Lymphoma Fact Sheet.

The Lymphoma Research Foundation welcomes the Double Hit Lymphoma Foundation (DHLF) supporters. LRF is committed to continuing the important work of providing educational opportunities and resources to those impacted by double hit lymphoma.