Mantle Cell Lymphoma

Mantle Cell lymphoma is typically an aggressiveLymphomas that are fast growing and generally need to be treated immediately. Also called intermediate-grade or high-grade lymphomas., rare, form of non-Hodgkin lymphoma (NHL) that arises from cells originating in the “mantle zone.” MCL accounts for roughly six percent of all NHL cases in the United States.

Frequently, mantle cell lymphoma is diagnosed at a later stageThe extent of cancer in the body, including whether the disease has spread from the original site to other body parts. of disease and in most cases involves the gastrointestinal tract and bone marrowSpongy material found inside the bones containing stem cells that develop into three types of cells: red blood cells that deliver oxygen to the body and take away carbon dioxide; white blood cells that protect the body from infection; and platelets. Overproduction of a protein called cyclin D1 in the lymphoma cells is found in more than 90 percent of patients with MCL. Identification of excess cyclin D1 from a biopsyRemoval of a small piece of tissue for evaluation under a microscope. is considered a very sensitive tool for diagnosing MCL. One-quarter to one-half of patients with MCL also have higher-than-normal levels of certain proteins that circulate in the blood, such as lactate dehydrogenase (LDH)An enzyme found in the blood. Higher levels of LDH suggest that the lymphoma may be more aggressive. and beta-2 microglobulin. Measuring these and other proteins can help physicians determine how aggressive an individual patient’s MCL is and may guide therapy decisions.

To learn more about MCL, download the Mantle Cell Lymphoma Fact Sheet. We would also encourage you to download our award winning mobile app, Focus on Lymphoma, which provides you comprehensive content and unique tools to help manage your disease.